TCBG Profile
| Chris Chipot has been working on the development of molecular simulation methodologies, with a particular focus on free-energy calculations, enhanced-sampling techniques, and quantitative characterization of rare events in complex molecular systems. His research is driven by the belief that advances in statistical mechanics, numerical methods, and machine learning must be tightly integrated with challenging applications in chemistry and biophysics in order to produce lasting conceptual and methodological progress. His work spans molecular recognition, membrane transport, conformational transitions, and biomolecular self-assembly, with particular emphasis on the structure, dynamics, and function of membrane proteins. His collaborations include the development of the widely used biomolecular simulation program NAMD since 2001, as well as numerous interdisciplinary projects in computational chemistry, structural biology, and soft condensed matter. He has contributed to the development of rigorous methodologies for computing free energies and reaction pathways, which are now routinely employed to investigate molecular processes ranging from ligand binding to protein conformational changes. He also leads long-standing international collaborations bridging Europe and the United States. Chris Chipot received his PhD in theoretical chemistry from Henri Poincaré University, France, in 1994. Following postdoctoral research in the Department of Pharmaceutical Chemistry at the University of California, San Francisco, and at the NASA Ames Research Center, he joined the CNRS at the University of Lorraine in 1996. He obtained his habilitation in 2000 and was promoted to research director in 2006. He is an adjunct faculty in the Department of Physics at the University of Illinois Urbana-Champaign, and visiting associate professor in the Department of Biochemistry and Molecular Biology at the University of Chicago. He is also the recipient of an Advanced Grant from the European Research Council, and a senior editor of The Journal of Physical Chemistry. |  Chris Chipot |
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