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Activation of coagulation factor X (FX) is arguably the most important step in the formation of blood clots. When tissues are damaged by external injury, FX activation is initiated by the formation of a complex between FVIIa and tissue factor, which binds and activates FX after anchoring into negatively charged cellular membranes. This key step involves the formation of a tripartite complex on the membrane, which was earlier modeled by Resource researchers and published in Blood Advances. In collaboration with the Ohi lab and Morrissey lab at the University of Michigan, the previous model is now largely confirmed by the first cryo-EM structure of the complex on the membrane, a study reported as a cover story in Blood.

Editorials

The Future of Biomolecular Modeling

A 2015 TCBG Symposium brought together scientists from across the Midwest to brainstorm about what's on the horizon for computational modeling. See a summary of what these experts foresee. Read more

Photosynthesis Unraveled

Go behind the scenes to examine the myriad roles Illinois researchers have played to explain photosynthesis: quantum physicist, structural biologist, forensic scientist, and computational biophysicist. By Lisa Pollack. Read more

Announcements

  • Cade Duckworth awarded prestigious 2026-27 MCB/Biophysics Graduate Fellowship
  • Yupeng Li-Beckman Institute Graduate Fellow
  • Restricted Surface Diffusion of Cytochromes on Bioenergetic Membranes with Anionic Lipids
  • Going Differently at Cancer


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