From: Georcki Ropon (
Date: Sat Nov 20 2021 - 13:35:42 CST

Hi Pietra,

For more complex neutralization you can use cionize , I use it for high charged systems (DNA, Ribosomes, etc,) <>



> On Nov 20, 2021, at 10:11, Francesco Pietra <> wrote:
> Hello
> I am trying to carry out MD with a mono-positively charged organic molecule (small molecule, "natural product") in chloroform.
> It seems to me that there is no point - or no easy way - to neutralize. That mono-positively chrged molecule (NMR identified) represents one of the species in a complex environment containing the MsOH strong acid, and where the prevalent existing base is also an organic molecule
> thanks for advice
> francesco pietra